CLCNKA and KRT39

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCNKA	KRT39
Description		chloride voltage-gated channel Ka	keratin 39
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex	Cytosol Cytoskeleton Intermediate Filament Keratin Filament
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Stimuli-sensing channels	Keratinization Formation of the cornified envelope
Drugs		Niflumic acid Talniflumate
Diseases		Bartter syndrome
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511	34 interacting genes: ANKS1A ARMC7 BEX2 C1orf216 CCDC196 CLCNKA FAM110A GFAP HGS IGFN1 KDM1A KLHL38 KRT1 KRT2 KRT3 KRT6B KRT74 KRT76 KRT78 KRT81 KRT83 KRT85 KRT86 LMO4 PPL PRPF18 SCNM1 SHC3 SMARCE1 TGM7 TXLNB UBASH3A VPS9D1 ZNF417
Entrez ID		1187	390792
HPRD ID		03608	13750
Ensembl ID		ENSG00000186510	ENSG00000196859
Uniprot IDs		P51800	Q6A163
PDB IDs		2PFI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratinization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Peptide Cross-linking
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