CLCNKA and KRTAP21-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCNKA	KRTAP21-2
Description		chloride voltage-gated channel Ka	keratin associated protein 21-2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex	Cytosol Intermediate Filament
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels	Keratinization
Drugs		Niflumic acid Talniflumate
Diseases		Bartter syndrome
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511	30 interacting genes: ADAMTSL4 ATXN1L BEX2 CLCNKA DMRTB1 EFEMP1 FAM221A FOXD2 GATA2 KRTAP10-1 KRTAP12-2 KRTAP26-1 LCE1A LCE2A LCE5A MKRN3 NTN4 PLSCR4 POU4F2 PRR13 RNF38 RNF44 SMARCC1 SMN1 SMN2 SNRPC SPAG8 TCF7L2 VENTX ZIC1
Entrez ID		1187	337978
HPRD ID		03608	11215
Ensembl ID		ENSG00000186510	ENSG00000187026
Uniprot IDs		P51800	Q3LI59
PDB IDs		2PFI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination	Developmental Process Sequence-specific DNA Binding SMN Complex Cajal Body Spliceosomal SnRNP Assembly Gemini Of Cajal Bodies Keratinization SMN-Sm Protein Complex DNA-templated Transcription Termination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?