WDR19 and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		WDR19	RIPK4
Description		WD repeat domain 19	receptor interacting serine/threonine kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Cytoskeleton Plasma Membrane Cilium Intraciliary Transport Particle A Motile Cilium Photoreceptor Connecting Cilium Cell Projection Ciliary Tip Non-motile Cilium	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Smoothened Signaling Pathway Gonad Development Cell Projection Organization Embryonic Limb Morphogenesis Embryonic Camera-type Eye Development Intraciliary Retrograde Transport Ear Morphogenesis Receptor Clustering Cilium Organization Embryonic Cranial Skeleton Morphogenesis Nervous System Process Digestive System Development Cilium Assembly Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Myotome Development Protein-containing Complex Assembly Protein Localization To Membrane Protein Localization To Ciliary Membrane	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases		Asphyxiating thoracic dystrophy; Jeune syndrome
GWAS		Cognitive function ( 24684796) Sensorimotor dexterity ( 31596458)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		2 interacting genes: PTGER4 RIPK4	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		57728	54101
HPRD ID		10489	10419
Ensembl ID		ENSG00000157796	ENSG00000183421
Uniprot IDs		B4DGR6 Q8NEZ3	Q96T11 Q9H4D1
PDB IDs		8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Negative Regulation Of Cellular Extravasation Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus T-helper Cell Differentiation Regulation Of Cellular Extravasation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E T Cell Differentiation Involved In Immune Response	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
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