WDR19 and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		WDR19	PTGER4
Description		WD repeat domain 19	prostaglandin E receptor 4
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Cytoskeleton Plasma Membrane Cilium Intraciliary Transport Particle A Motile Cilium Photoreceptor Connecting Cilium Cell Projection Ciliary Tip Non-motile Cilium	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Smoothened Signaling Pathway Gonad Development Cell Projection Organization Embryonic Limb Morphogenesis Embryonic Camera-type Eye Development Intraciliary Retrograde Transport Ear Morphogenesis Receptor Clustering Cilium Organization Embryonic Cranial Skeleton Morphogenesis Nervous System Process Digestive System Development Cilium Assembly Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Myotome Development Protein-containing Complex Assembly Protein Localization To Membrane Protein Localization To Ciliary Membrane	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Hedgehog 'off' state Intraflagellar transport	Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases		Asphyxiating thoracic dystrophy; Jeune syndrome
GWAS		Cognitive function ( 24684796) Sensorimotor dexterity ( 31596458)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		2 interacting genes: PTGER4 RIPK4	42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		57728	5734
HPRD ID		10489	03350
Ensembl ID		ENSG00000157796	ENSG00000171522
Uniprot IDs		B4DGR6 Q8NEZ3	A0PJF5 P35408
PDB IDs		8BBF 8BBG 8FGW 8FH3	5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Negative Regulation Of Cellular Extravasation Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus T-helper Cell Differentiation Regulation Of Cellular Extravasation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E T Cell Differentiation Involved In Immune Response	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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