NSMCE2 and TSNAX

Number of citations of the paper that reports this interaction (PubMedID 16055714)
51

Data Source:
BioGRID (enzymatic study)

		NSMCE2	TSNAX
Description		NSE2 SUMO ligase component of SMC5/6 complex	translin associated factor X
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body PML Body Smc5-Smc6 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm Endoribonuclease Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	DNA Binding Single-stranded DNA Binding RNA Binding RNA Endonuclease Activity Protein Binding A2A Adenosine Receptor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence Chromatin Looping	Spermatogenesis Cell Differentiation SiRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Pathways		SUMOylation of DNA damage response and repair proteins	Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28	41 interacting genes: AIMP1 AKAP9 BEX3 BLOC1S5 C1D CARD9 CDK5RAP2 CEBPA CEP68 CKAP4 COG6 EMILIN1 GADD45G GOLGA3 GPATCH2 GRIPAP1 HMGB2 KCNE4 KRT31 LDB2 LDOC1 LZTS2 MECOM MRFAP1L1 MTCL2 NSMCE2 NTAQ1 PBXIP1 PRPF18 RALYL RFC5 SPRED2 SUN1 SYCE2 SYT17 TCF12 TCP11L1 TSN TSNAXIP1 UBE2I VPS28
Entrez ID		286053	7257
HPRD ID		08131	04270
Ensembl ID		ENSG00000156831	ENSG00000116918
Uniprot IDs		A0A087WTZ8 Q96MF7	Q99598
PDB IDs		2YU4	3PJA 3QB5
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding Endoribonuclease Complex A2A Adenosine Receptor Binding DNA Secondary Structure Binding Interchromatin Granule Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Sex Chromosome Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process SiRNA Processing Smc5-Smc6 Complex
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