NSMCE2 and ETV1

Number of citations of the paper that reports this interaction (PubMedID 16055714)
51

Data Source:
BioGRID (enzymatic study)

		NSMCE2	ETV1
Description		NSE2 SUMO ligase component of SMC5/6 complex	ETS variant transcription factor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body PML Body Smc5-Smc6 Complex	Chromatin Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence Chromatin Looping	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Axon Guidance Muscle Organ Development Mechanosensory Behavior Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases			Prostate cancer Ewing's sarcoma
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Extrahepatic cholangiocarcinoma ( 34315874) Height ( 28552196 31217584) Intraocular pressure ( 30591961) Lymphocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Renal underexcretion gout ( 32238385) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 32499647 24509480) Verbal declarative memory ( 25648963) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28	20 interacting genes: ATR CCND3 EP300 ERG JUN KAT2B KCNA2 MAPK14 MAPK3 MAPK8 MAPKAPK2 NCOA2 NCOA3 NFE2L2 NSMCE2 PRKACA RPS6KA1 RPS6KA5 SPI1 UBE2I
Entrez ID		286053	2115
HPRD ID		08131	02765
Ensembl ID		ENSG00000156831	ENSG00000006468
Uniprot IDs		A0A087WTZ8 Q96MF7	B5MCT2 B7Z2C9 P50549
PDB IDs		2YU4	4AVP 4BNC 5ILS
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding Endoribonuclease Complex A2A Adenosine Receptor Binding DNA Secondary Structure Binding Interchromatin Granule Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Sex Chromosome Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process SiRNA Processing Smc5-Smc6 Complex	Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Serine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Transferase Activity Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Kinase Activity TORC1 Signaling Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription TOR Signaling Positive Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Nucleus Negative Regulation Of Metabolic Process Regulation Of Gene Expression Kinase Activity Response To Hormone Regulation Of Multicellular Organismal Process Cellular Response To Stress Signal Transduction Cellular Response To Nutrient Levels Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Nutrient Levels MAP Kinase Activity Cellular Senescence Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Component Organization Protein Phosphorylation Positive Regulation Of Cyclase Activity Protein Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Stress-activated MAPK Cascade Response To Mechanical Stimulus
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