NYAP2 and WASF1

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		NYAP2	WASF1
Description		neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	WASP family member 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) LDL cholesterol levels in HIV infection ( 33109212) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Triglyceride levels in HIV infection ( 33109212) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1	38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10
Entrez ID		57624	8936
HPRD ID		13867	05434
Ensembl ID		ENSG00000144460	ENSG00000112290
Uniprot IDs		A0A8V8N5G5 Q9P242	Q92558
PDB IDs			3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Lamellipodium Organization Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cell Projection Assembly Postsynapse Lamellipodium Assembly Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Small GTPase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Organelle Organization Neuron Projection Extension Cell Projection Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Ruffle Developmental Cell Growth Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Paraxial Mesoderm Morphogenesis	Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway
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