NYAP2 and MORN4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NYAP2	MORN4
Description		neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	MORN repeat containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Stereocilium Stereocilium Tip Filopodium Tip Cell Projection Actin-based Cell Projection
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis	Response To Axon Injury
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) LDL cholesterol levels in HIV infection ( 33109212) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Triglyceride levels in HIV infection ( 33109212) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378) Walking pace ( 33128006)	Bell's palsy ( 33602968)
Interacting Genes		6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1	30 interacting genes: APOA5 BEND3 CRTAC1 DNAJC9 EXOSC8 F2RL1 GOPC GUCD1 HMMR INO80E KRT25 KRT27 MAGI2 NUTM1 NUTM2F NYAP2 PLAGL2 RHOQ SEPTIN11 SEPTIN6 SNCB SSX2IP SYTL2 TCF12 TCF4 TRIM23 TRIM44 WASHC1 WBP11 ZNF131
Entrez ID		57624	118812
HPRD ID		13867	16584
Ensembl ID		ENSG00000144460	ENSG00000171160
Uniprot IDs		A0A8V8N5G5 Q9P242	A6XB87 Q8NDC4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Lamellipodium Organization Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cell Projection Assembly Postsynapse Lamellipodium Assembly Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Small GTPase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Organelle Organization Neuron Projection Extension Cell Projection Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Ruffle Developmental Cell Growth Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Paraxial Mesoderm Morphogenesis	Positive Regulation Of Pseudopodium Assembly Cell Division Site Septin Ring Septin Complex Golgi-associated Vesicle Membrane
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