NYAP2

Description		neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
Image		No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding
	Biological Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) LDL cholesterol levels in HIV infection ( 33109212) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Triglyceride levels in HIV infection ( 33109212) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1
Entrez ID		57624
HPRD ID		13867
Ensembl ID		ENSG00000144460
Uniprot IDs		A0A8V8N5G5 Q9P242
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Lamellipodium Organization Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cell Projection Assembly Postsynapse Lamellipodium Assembly Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Small GTPase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Organelle Organization Neuron Projection Extension Cell Projection Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Ruffle Developmental Cell Growth Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Paraxial Mesoderm Morphogenesis
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