NYAP2 and NCKAP1

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		NYAP2	NCKAP1
Description		neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	NCK associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component		Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) LDL cholesterol levels in HIV infection ( 33109212) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Triglyceride levels in HIV infection ( 33109212) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378) Walking pace ( 33128006)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1	16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG
Entrez ID		57624	10787
HPRD ID		13867	05353
Ensembl ID		ENSG00000144460	ENSG00000061676
Uniprot IDs		A0A8V8N5G5 Q9P242	A0A994J4I5 A0A994J6K9 Q9Y2A7
PDB IDs			3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Lamellipodium Organization Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cell Projection Assembly Postsynapse Lamellipodium Assembly Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Small GTPase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Organelle Organization Neuron Projection Extension Cell Projection Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Ruffle Developmental Cell Growth Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Paraxial Mesoderm Morphogenesis	SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
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