ISLR2 and NKG7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ISLR2	NKG7
Description		immunoglobulin superfamily containing leucine rich repeat 2	natural killer cell granule protein 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Lysosome Plasma Membrane Membrane Cytolytic Granule Cytolytic Granule Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Nervous System Development Positive Regulation Of Axon Extension	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Killing Of Cells Of Another Organism CD4-positive, Alpha-beta T Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Protozoan Natural Killer Cell Degranulation Positive Regulation Of Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B	49 interacting genes: AGTRAP AMIGO1 AQP6 ARL13B ATP6AP2 BAMBI CD53 CD79A CLDN7 CLEC2D CLEC4E CLSTN3 CREB3 EBP EDA2R ERGIC3 FAM209A FAM210B FFAR2 FKBP7 FNDC9 GJA5 GORAB GPX8 ISLR2 KLRC1 LHFPL5 LMNA MFSD6 MGST3 MS4A3 MSR1 MUC1 OPRK1 PEX12 RAMP1 RNF24 SLC10A1 SLC18A2 SLC30A8 SLC35H1 STOM STX1A TLCD4 TMEM106C TMEM130 TMEM139 TMEM80 TMEM88
Entrez ID		57611	4818
HPRD ID		13865	16188
Ensembl ID		ENSG00000167178	ENSG00000105374
Uniprot IDs		Q6UXK2	A0A0B4J2A6 Q16617
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cytolytic Granule Membrane Apical Plasma Membrane Urothelial Plaque Regulation Of Lysosomal Membrane Permeability Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Natural Killer Cell Degranulation Immune Response To Tumor Cell Signaling Receptor Regulator Activity Ceramide Binding Bleb Assembly Membrane Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Lysosome Organization Lysosomal Membrane Organization Regulation Of Skeletal Muscle Contraction Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Membrane Plasma Membrane Protein Binding
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