ISLR2 and UPK1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ISLR2	UPK1B
Description		immunoglobulin superfamily containing leucine rich repeat 2	uroplakin 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Nervous System Development Positive Regulation Of Axon Extension	Response To Bacterium Epithelial Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)
Interacting Genes		6 interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B	59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1
Entrez ID		57611	7348
HPRD ID		13865	03853
Ensembl ID		ENSG00000167178	ENSG00000114638
Uniprot IDs		Q6UXK2	O75841
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cytolytic Granule Membrane Apical Plasma Membrane Urothelial Plaque Regulation Of Lysosomal Membrane Permeability Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Natural Killer Cell Degranulation Immune Response To Tumor Cell Signaling Receptor Regulator Activity Ceramide Binding Bleb Assembly Membrane Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Lysosome Organization Lysosomal Membrane Organization Regulation Of Skeletal Muscle Contraction Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity
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