STARD9 and SVIL

Number of citations of the paper that reports this interaction (PubMedID 20309963)
81

Data Source:
BioGRID (two hybrid)

		STARD9	SVIL
Description		StAR related lipid transfer domain containing 9	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centriole Cytoskeleton	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Lipid Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Microtubule-based Movement Spindle Assembly	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glucose homeostasis traits ( 25524916) MGMT methylation in smokers ( 26183928)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		5 interacting genes: CDK5RAP2 HERPUD1 NDUFA7 PPP1CC SVIL	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		57519	6840
HPRD ID		15442	04992
Ensembl ID		ENSG00000159433	ENSG00000197321
Uniprot IDs		Q9P2P6	A0A6I8PIX7 O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cytoskeleton Organization Cleavage Furrow Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Microtubule Organizing Center Regulation Of Protein Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cytoskeleton Organization Regulation Of Protein-containing Complex Disassembly Lewy Body Core Cerebellar Granular Layer Development Chromosome Segregation Cytoskeleton Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization	Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process
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