SERINC1 and PAX8

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		SERINC1	PAX8
Gene Name		serine incorporator 1	paired box 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Protein Binding L-serine Transmembrane Transporter Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process L-serine Transport Positive Regulation Of Transferase Activity	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Central Nervous System Development Anatomical Structure Morphogenesis Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways
Drugs
Diseases
GWAS			Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		4 interactors: CYP39A1 MAK PAX8 ZMYND10	11 interactors: ANXA7 CHUK CXCL9 EP300 ID2 NKX2-1 PKM POU2AF1 SERINC1 SMAD3 WBP2
Entrez ID		57515	7849
HPRD ID		15480	01335
Ensembl ID		ENSG00000111897	ENSG00000125618
Uniprot IDs		Q9NRX5	Q06710 R9W7C9
PDB IDs			2K27
Enriched GO Terms of Interacting Partners?		Regulation Of Thyroid-stimulating Hormone Secretion Positive Regulation Of Metanephric DCT Cell Differentiation Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Thyroid Hormone Generation Bile Acid Catabolic Process Kidney Rudiment Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Thyroid-stimulating Hormone Signaling Pathway Metanephric Nephron Tubule Formation Metanephric Comma-shaped Body Morphogenesis Metanephric Tubule Formation Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Inner Dynein Arm Assembly Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Metanephric S-shaped Body Morphogenesis Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Pronephros Development S-shaped Body Morphogenesis Outer Dynein Arm Assembly Motile Cilium Assembly Metanephric Distal Tubule Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cholesterol Catabolic Process Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Tubule Morphogenesis Distal Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Axonemal Dynein Complex Assembly Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Otic Vesicle Development Mesenchymal To Epithelial Transition Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Bile Acid Biosynthetic Process Steroid Catabolic Process Specification Of Organ Identity Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Mammary Gland Epithelial Cell Proliferation Tissue Development Organ Morphogenesis Thyroid Gland Development Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Differentiation Regulation Of Metabolic Process Immune Response Immune System Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Osteoblast Differentiation Mammary Gland Lobule Development Mammary Gland Alveolus Development Tube Development Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Digestive Tract Morphogenesis Response To Lipid Transcription From RNA Polymerase II Promoter Histone H2B Acetylation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Organic Cyclic Compound Negative Regulation Of Ossification Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Somitogenesis Neuron Fate Commitment Endoderm Development Epithelial Cell Proliferation Protein Stabilization Response To External Stimulus
Tagcloud ?			absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid
Tagcloud (Difference) ?			absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid
Tagcloud (Intersection) ?