SERINC1 and MAK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SERINC1	MAK
Description		serine incorporator 1	male germ cell associated kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Midbody Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Mitotic Spindle
	Molecular Function	Protein Binding Acetyltransferase Activator Activity Protein-macromolecule Adaptor Activity	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Membrane Biogenesis	Protein Phosphorylation Spermatogenesis Cell Differentiation Intracellular Signal Transduction Intraciliary Transport Photoreceptor Cell Maintenance Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Cilium Assembly Negative Regulation Of Non-motile Cilium Assembly Non-motile Cilium Assembly
Pathways		Serine metabolism
Drugs
Diseases
GWAS		Plateletcrit ( 27863252 32888494)	Menopause (age at onset) ( 26414677) Recurrent major depressive disorder ( 29317602) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		9 interacting genes: AQP9 CREB3 CYP39A1 FFAR3 GPR42 GPX8 MAK PAX8 ZMYND10	9 interacting genes: ANAPC11 APP FBXO7 FZR1 NDUFB7 PPP2CB SERINC1 SLAMF7 SND1
Entrez ID		57515	4117
HPRD ID		15480	01101
Ensembl ID		ENSG00000111897	ENSG00000111837
Uniprot IDs		Q9NRX5	A0A140VK28 A0A6Q8PG01 A0A6Q8PH30 F8VBW7 P20794 Q8IXN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Hormone Metabolic Process Negative Regulation Of Non-motile Cilium Assembly Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Regulation Of Thyroid-stimulating Hormone Secretion Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Deacetylase Activity Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Cilium Assembly Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Positive Regulation Of Thyroid Hormone Generation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Intracellular Membrane-bounded Organelle Glycerol Channel Activity Metanephric Tubule Formation Negative Regulation Of Somatic Stem Cell Population Maintenance Release From Viral Latency Urea Transmembrane Transporter Activity Pyrimidine Nucleobase Transport Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis S-shaped Body Morphogenesis CCR1 Chemokine Receptor Binding Purine Nucleobase Transmembrane Transport Glycerol Transmembrane Transport Pronephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Otic Vesicle Development Cholesterol Catabolic Process	Response To Lead Ion Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Polyubiquitination Regulation Of Cell Cycle Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite RNAi Effector Complex Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition G Protein-coupled Receptor Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Lewy Body Core Protein K48-linked Ubiquitination Regulation Of Cell Cycle Phase Transition DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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