SERINC1 and GPR42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SERINC1	GPR42
Description		serine incorporator 1	G protein-coupled receptor 42
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Acetyltransferase Activator Activity Protein-macromolecule Adaptor Activity	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Membrane Biogenesis	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Serine metabolism
Drugs
Diseases
GWAS		Plateletcrit ( 27863252 32888494)
Interacting Genes		9 interacting genes: AQP9 CREB3 CYP39A1 FFAR3 GPR42 GPX8 MAK PAX8 ZMYND10	110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		57515	2866
HPRD ID		15480	16033
Ensembl ID		ENSG00000111897	ENSG00000126251
Uniprot IDs		Q9NRX5	A0A0K0PUY3 O15529
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Hormone Metabolic Process Negative Regulation Of Non-motile Cilium Assembly Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Regulation Of Thyroid-stimulating Hormone Secretion Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Deacetylase Activity Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Cilium Assembly Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Positive Regulation Of Thyroid Hormone Generation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Intracellular Membrane-bounded Organelle Glycerol Channel Activity Metanephric Tubule Formation Negative Regulation Of Somatic Stem Cell Population Maintenance Release From Viral Latency Urea Transmembrane Transporter Activity Pyrimidine Nucleobase Transport Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis S-shaped Body Morphogenesis CCR1 Chemokine Receptor Binding Purine Nucleobase Transmembrane Transport Glycerol Transmembrane Transport Pronephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Otic Vesicle Development Cholesterol Catabolic Process	Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion
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