SERINC1 and CYP39A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SERINC1	CYP39A1
Gene Name		serine incorporator 1	cytochrome P450, family 39, subfamily A, polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding L-serine Transmembrane Transporter Activity	Iron Ion Binding Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Heme Binding 24-hydroxycholesterol 7alpha-hydroxylase Activity
	Biological Process	Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process L-serine Transport Positive Regulation Of Transferase Activity	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Xenobiotic Metabolic Process Digestion Bile Acid Metabolic Process Sterol Metabolic Process Bile Acid Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 24-hydroxycholesterol Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CYP39A1 MAK PAX8 ZMYND10	4 interactors: GLUL ORM2 SERINC1 SMYD3
Entrez ID		57515	51302
HPRD ID		15480	07067
Ensembl ID		ENSG00000111897	ENSG00000146233
Uniprot IDs		Q9NRX5	B7Z786 Q9NYL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Thyroid-stimulating Hormone Secretion Positive Regulation Of Metanephric DCT Cell Differentiation Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Thyroid Hormone Generation Bile Acid Catabolic Process Kidney Rudiment Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Thyroid-stimulating Hormone Signaling Pathway Metanephric Nephron Tubule Formation Metanephric Comma-shaped Body Morphogenesis Metanephric Tubule Formation Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Inner Dynein Arm Assembly Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Metanephric S-shaped Body Morphogenesis Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Pronephros Development S-shaped Body Morphogenesis Outer Dynein Arm Assembly Motile Cilium Assembly Metanephric Distal Tubule Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cholesterol Catabolic Process Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Tubule Morphogenesis Distal Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Axonemal Dynein Complex Assembly Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Otic Vesicle Development Mesenchymal To Epithelial Transition Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Bile Acid Biosynthetic Process Steroid Catabolic Process Specification Of Organ Identity Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis
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