SERINC1 and CYP39A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SERINC1	CYP39A1
Description		serine incorporator 1	cytochrome P450 family 39 subfamily A member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Acetyltransferase Activator Activity Protein-macromolecule Adaptor Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid 7-alpha-hydroxylase Activity Steroid Hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Membrane Biogenesis	Lipid Metabolic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Cholesterol Homeostasis
Pathways		Serine metabolism	Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols
Drugs
Diseases
GWAS		Plateletcrit ( 27863252 32888494)	Normal facial asymmetry (deformation magnitude) ( 30631343)
Interacting Genes		9 interacting genes: AQP9 CREB3 CYP39A1 FFAR3 GPR42 GPX8 MAK PAX8 ZMYND10	4 interacting genes: GLUL ORM2 SERINC1 SMYD3
Entrez ID		57515	51302
HPRD ID		15480	07067
Ensembl ID		ENSG00000111897	ENSG00000146233
Uniprot IDs		Q9NRX5	A0A087WTD2 B7Z786 Q9NYL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Hormone Metabolic Process Negative Regulation Of Non-motile Cilium Assembly Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Regulation Of Thyroid-stimulating Hormone Secretion Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Deacetylase Activity Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Cilium Assembly Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Positive Regulation Of Thyroid Hormone Generation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Intracellular Membrane-bounded Organelle Glycerol Channel Activity Metanephric Tubule Formation Negative Regulation Of Somatic Stem Cell Population Maintenance Release From Viral Latency Urea Transmembrane Transporter Activity Pyrimidine Nucleobase Transport Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis S-shaped Body Morphogenesis CCR1 Chemokine Receptor Binding Purine Nucleobase Transmembrane Transport Glycerol Transmembrane Transport Pronephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Otic Vesicle Development Cholesterol Catabolic Process	Glutamine Synthetase Activity Intracellular Ammonium Homeostasis Glutamine Biosynthetic Process Ammonium Homeostasis L-glutamate Catabolic Process Membrane Biogenesis RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Protein Localization To Nucleolus Acetyltransferase Activator Activity
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