OAS3

Gene Name		2-5-oligoadenylate synthetase 3, 100kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) HDL cholesterol ( 21909109) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-protein Interactions		5 interactors: DHX30 EIF6 FTSJ3 IFRD2 MAVS
Entrez ID		4940
HPRD ID		04519
Ensembl ID		ENSG00000111331
Uniprot IDs		Q9Y6K5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of IP-10 Production Enzyme-directed RRNA 2'-O-methylation Ribosome Biogenesis Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production RIG-I Signaling Pathway Regulation Of Peroxisome Organization Mature Ribosome Assembly Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Ribonucleoprotein Complex Biogenesis Cellular Response To Exogenous DsRNA Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Import Into Nucleus, Translocation RRNA Methylation Positive Regulation Of Type I Interferon-mediated Signaling Pathway RRNA Modification Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Interferon-alpha Production Ribosomal Large Subunit Biogenesis Positive Regulation Of Interferon-beta Production Ribosome Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response To Virus By Host Positive Regulation Of Interleukin-8 Production Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Chemokine Production Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production RNA Methylation
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase