OAS3

Name	2'-5'-oligoadenylate synthetase 3
Structure
Interactors	6 interactors: DHX30 EIF6 FTSJ3 IFRD2 MAVS RNF10
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Immune System Process Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Antiviral Innate Immune Response Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways	Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
GWAS	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Body mass index ( 26426971 ) Chronic lymphocytic leukemia ( 28165464 ) HDL cholesterol ( 21909109 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Low HDL-cholesterol levels ( 31006500 ) Myocardial infarction ( 30226566 ) Response to fenofibrate (adiponectin levels) ( 23149075 ) Right-sided colonic diverticulosis ( 31089239 )
Entrez ID	4940
HPRD ID	04519
Ensembl ID	ENSG00000111331
Uniprot IDs	A0A7P0T8S7 Q9Y6K5
PDB IDs	4S3N
GO Terms Enriched among Interactors ?	Maturation Of 5.8S RRNA Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Maturation Of LSU-rRNA Assembly Of Large Subunit Precursor Of Preribosome Ribosome Binding Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization RNA 2'-O-methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity Lamin Filament Cytosolic Ribosome Assembly Negative Regulation Of Translation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA (guanine) Methyltransferase Activity RRNA Methyltransferase Activity RRNA Processing Protein-RNA Complex Assembly Mitochondrial Large Ribosomal Subunit Assembly Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Negative Regulation Of Schwann Cell Proliferation G-quadruplex RNA Binding RRNA Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ribosomal Subunit Export From Nucleus Positive Regulation Of Dendritic Cell Cytokine Production Preribosome, Small Subunit Precursor