OAS3 and IFRD2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OAS3	IFRD2
Gene Name		2-5-oligoadenylate synthetase 3, 100kDa	interferon-related developmental regulator 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) HDL cholesterol ( 21909109) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		5 interactors: DHX30 EIF6 FTSJ3 IFRD2 MAVS	4 interactors: APP NEDD4L OAS3 POT1
Entrez ID		4940	7866
HPRD ID		04519	04101
Ensembl ID		ENSG00000111331	ENSG00000214706
Uniprot IDs		Q9Y6K5	Q12894 Q9UJ88
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of IP-10 Production Enzyme-directed RRNA 2'-O-methylation Ribosome Biogenesis Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production RIG-I Signaling Pathway Regulation Of Peroxisome Organization Mature Ribosome Assembly Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Ribonucleoprotein Complex Biogenesis Cellular Response To Exogenous DsRNA Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Import Into Nucleus, Translocation RRNA Methylation Positive Regulation Of Type I Interferon-mediated Signaling Pathway RRNA Modification Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Interferon-alpha Production Ribosomal Large Subunit Biogenesis Positive Regulation Of Interferon-beta Production Ribosome Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response To Virus By Host Positive Regulation Of Interleukin-8 Production Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Chemokine Production Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production RNA Methylation	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Ribonuclease Activity Telomere Formation Via Telomerase Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Nucleobase-containing Compound Metabolic Process Neuron Remodeling Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metal Ion Homeostasis Negative Regulation Of Sodium Ion Transport Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Nitrogen Compound Metabolic Process Cellular Cation Homeostasis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Sodium Ion Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Cellular Chemical Homeostasis Nitrogen Compound Metabolic Process Ventricular Cardiac Muscle Cell Action Potential Cellular Copper Ion Homeostasis Regulation Of Telomere Maintenance Ion Homeostasis Regulation Of Protein Localization To Cell Surface
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Difference) ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Intersection) ?