OAS3 and FTSJ3

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OAS3	FTSJ3
Description		2'-5'-oligoadenylate synthetase 3	FtsJ RNA 2'-O-methyltransferase 3
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GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor Preribosome, Small Subunit Precursor
	Molecular Function	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity RNA 2'-O-methyltransferase Activity
	Biological Process	Immune System Process Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Antiviral Innate Immune Response Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Methylation RRNA Processing RRNA Methylation Methylation Ribosome Biogenesis
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464) HDL cholesterol ( 21909109) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Low HDL-cholesterol levels ( 31006500) Myocardial infarction ( 30226566) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239)	Hemoglobin levels ( 32327693)
Interacting Genes		6 interacting genes: DHX30 EIF6 FTSJ3 IFRD2 MAVS RNF10	12 interacting genes: CSNK2A1 EIF2AK2 EIF4ENIF1 FANCG MAGEB4 OAS3 OGT RNF10 SAT1 SNW1 SSX2 SSX2B
Entrez ID		4940	117246
HPRD ID		04519	17024
Ensembl ID		ENSG00000111331	ENSG00000108592
Uniprot IDs		A0A7P0T8S7 Q9Y6K5	Q8IY81
PDB IDs		4S3N	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8IR1
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Maturation Of LSU-rRNA Assembly Of Large Subunit Precursor Of Preribosome Ribosome Binding Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization RNA 2'-O-methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity Lamin Filament Cytosolic Ribosome Assembly Negative Regulation Of Translation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA (guanine) Methyltransferase Activity RRNA Methyltransferase Activity RRNA Processing Protein-RNA Complex Assembly Mitochondrial Large Ribosomal Subunit Assembly Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Negative Regulation Of Schwann Cell Proliferation G-quadruplex RNA Binding RRNA Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ribosomal Subunit Export From Nucleus Positive Regulation Of Dendritic Cell Cytokine Production Preribosome, Small Subunit Precursor	Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Sin3-type Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Regulation Of Translation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferase Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production Negative Regulation Of Viral Genome Replication Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Proteasomal Protein Catabolic Process Membraneless Organelle Assembly Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Double-stranded RNA Binding Antiviral Innate Immune Response Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Positive Regulation Of Chemokine Production Spermidine Acetylation Putrescine Catabolic Process Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Translation Protein Localization To Vacuole Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Diamine N-acetyltransferase Activity Protein O-acetylglucosaminyltransferase Activity
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