OAS3 and MAVS

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		OAS3	MAVS
Gene Name		2-5-oligoadenylate synthetase 3, 100kDa	mitochondrial antiviral signaling protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	Signal Transducer Activity Protein Binding Protein Kinase Binding CARD Domain Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus, Translocation RIG-I Signaling Pathway Defense Response To Bacterium Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) HDL cholesterol ( 21909109) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		5 interactors: DHX30 EIF6 FTSJ3 IFRD2 MAVS	19 interactors: ABL1 BAG6 CALCOCO2 DDX58 IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 RIPK2 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF5 TRAF6 UBE4A
Entrez ID		4940	57506
HPRD ID		04519	13847
Ensembl ID		ENSG00000111331
Uniprot IDs		Q9Y6K5	M1P2Z0 Q7Z434
PDB IDs			2VGQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of IP-10 Production Enzyme-directed RRNA 2'-O-methylation Ribosome Biogenesis Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production RIG-I Signaling Pathway Regulation Of Peroxisome Organization Mature Ribosome Assembly Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Ribonucleoprotein Complex Biogenesis Cellular Response To Exogenous DsRNA Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Import Into Nucleus, Translocation RRNA Methylation Positive Regulation Of Type I Interferon-mediated Signaling Pathway RRNA Modification Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Interferon-alpha Production Ribosomal Large Subunit Biogenesis Positive Regulation Of Interferon-beta Production Ribosome Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response To Virus By Host Positive Regulation Of Interleukin-8 Production Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Chemokine Production Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production RNA Methylation	Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Response To Other Organism Response To Biotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Activation Of Innate Immune Response Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type I Interferon Production Defense Response Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Response To Virus Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Response To Bacterium Response To Organic Substance Response To Exogenous DsRNA Regulation Of Immune Response Positive Regulation Of Immune Response I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To External Stimulus Programmed Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Organic Substance Response To DsRNA Cell Death Cellular Response To Molecule Of Bacterial Origin Death Response To Interferon-gamma Response To Molecule Of Bacterial Origin Regulation Of Gene Expression Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Intracellular Receptor Signaling Pathway Positive Regulation Of Immune System Process
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu innate irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3
Tagcloud (Difference) ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu innate irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3
Tagcloud (Intersection) ?