ITGB5 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ITGB5	KRTAP1-3
Description		integrin subunit beta 5	keratin associated protein 1-3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Metal Ion Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Stress Fiber Assembly Symbiont Entry Into Host Cell Epithelial Cell-cell Adhesion Cell-cell Adhesion
Pathways		Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction	Keratinization
Drugs
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		3693	81850
HPRD ID		00949	12305
Ensembl ID		ENSG00000082781	ENSG00000221880
Uniprot IDs		L7RT22 P18084	Q8IUG1
PDB IDs		7S46 7S47 7S48
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Focal Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Cell Adhesion Actin Binding Z Disc Negative Regulation Of Programmed Cell Death Anchoring Junction Regulation Of Cell-substrate Adhesion Integrin Binding Cytoskeleton Organization Structural Molecule Activity Transforming Growth Factor Beta Binding Structural Constituent Of Skin Epidermis Positive Regulation Of Cell-substrate Adhesion M Band Protein Binding Wound Healing, Spreading Of Cells Extracellular Matrix Binding Actin Cytoskeleton Organization Supramolecular Fiber Organization Detection Of Muscle Stretch Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Actin Filament-based Process Growth Factor Binding Ruffle Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Migration Tissue Development Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Osteoblast Proliferation Microfibril Positive Regulation Of Bone Resorption Calcium Ion Binding Transcription Coregulator Activity Actin Crosslink Formation Cytoskeleton Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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