ITGB5 and PAK4

Number of citations of the paper that reports this interaction (PMID 12356872)
18

Data Source:
HPRD (in vivo, two hybrid)

		ITGB5	PAK4
Gene Name		integrin, beta 5	p21 protein (Cdc42/Rac)-activated kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome	Golgi Apparatus Focal Adhesion
	Molecular Function	Receptor Activity Integrin Binding Protein Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Signal Transduction Cell Proliferation Cell Growth Cell Migration Signal Transduction By Phosphorylation Intracellular Signal Transduction
Pathways		Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Axon guidance Activation of Rac Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17	19 interactors: APP CDC42 DLST FBXO25 FGFR2 GATAD2A GRB2 ITGAV ITGB5 LIMK1 POT1 RAN SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ
Entrez ID		3693	10298
HPRD ID		00949	05675
Ensembl ID		ENSG00000082781	ENSG00000130669
Uniprot IDs		L7RT22 P18084	O96013
PDB IDs			2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4L67
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis	Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Innate Immune Response Positive Regulation Of Cell Cycle Axonogenesis Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune Response Axon Development Defense Response Developmental Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neuron Projection Morphogenesis Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Establishment Of Golgi Localization Anatomical Structure Development Anatomical Structure Formation Involved In Morphogenesis Cell Death Death Axon Guidance Regulation Of Cell Death Cell Differentiation Positive Regulation Of Mitochondrion Organization Cell Morphogenesis Involved In Differentiation Blood Coagulation Hemostasis Signal Transduction Negative Regulation Of Catalytic Activity Nervous System Development Regulation Of Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Telomerase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Intracellular Transport Cell Projection Morphogenesis Regulation Of ERBB Signaling Pathway
Tagcloud ?		concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane	apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt frat1 gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 precise prevents ser33 thr41 transforming translocation transporter upregulation wnt
Tagcloud (Difference) ?		concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transmembrane	apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt frat1 gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 precise prevents ser33 thr41 translocation transporter upregulation wnt
Tagcloud (Intersection) ?		transforming