ITGB5 and STAB2

Number of citations of the paper that reports this interaction (PubMedID 22566688)
42

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ITGB5	STAB2
Description		integrin subunit beta 5	stabilin 2
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Metal Ion Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein-disulfide Reductase Activity Low-density Lipoprotein Particle Binding Cargo Receptor Activity
	Biological Process	Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Stress Fiber Assembly Symbiont Entry Into Host Cell Epithelial Cell-cell Adhesion Cell-cell Adhesion	Angiogenesis Endocytosis Receptor-mediated Endocytosis Cell Adhesion Hyaluronan Catabolic Process Defense Response To Bacterium Defense Response To Gram-positive Bacterium
Pathways		Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction	Hyaluronan metabolism Hyaluronan degradation Scavenging by Class H Receptors
Drugs			Hyaluronic acid
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	A body shape index ( 34021172) Adverse response to drug ( 30420678) Coronary restenosis ( 21878436) Daytime sleep phenotypes ( 27126917) Factor VIII levels ( 30586737) Low vWF levels ( 26486471) Monocyte count ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Sense of smell ( 26632684) Stem cell growth factor beta levels ( 27989323) Systemic lupus erythematosus ( 33493351) vWF and FVIII levels ( 21810271) vWF levels ( 20231535 30586737)
Interacting Genes		58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655	1 interacting genes: ITGB5
Entrez ID		3693	55576
HPRD ID		00949	10542
Ensembl ID		ENSG00000082781	ENSG00000136011
Uniprot IDs		L7RT22 P18084	Q8WWQ8
PDB IDs		7S46 7S47 7S48	5N86
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Focal Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Cell Adhesion Actin Binding Z Disc Negative Regulation Of Programmed Cell Death Anchoring Junction Regulation Of Cell-substrate Adhesion Integrin Binding Cytoskeleton Organization Structural Molecule Activity Transforming Growth Factor Beta Binding Structural Constituent Of Skin Epidermis Positive Regulation Of Cell-substrate Adhesion M Band Protein Binding Wound Healing, Spreading Of Cells Extracellular Matrix Binding Actin Cytoskeleton Organization Supramolecular Fiber Organization Detection Of Muscle Stretch Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Actin Filament-based Process Growth Factor Binding Ruffle Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Migration Tissue Development Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Osteoblast Proliferation Microfibril Positive Regulation Of Bone Resorption Calcium Ion Binding Transcription Coregulator Activity Actin Crosslink Formation Cytoskeleton Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Integrin Alphav-beta5 Complex Wound Healing, Spreading Of Epidermal Cells Wound Healing, Spreading Of Cells Epithelial Cell-cell Adhesion Stress Fiber Assembly Cell Adhesion Mediated By Integrin Integrin Complex Contractile Actin Filament Bundle Assembly Endodermal Cell Differentiation Formation Of Primary Germ Layer Actin Filament Bundle Assembly Actin Filament Bundle Organization Phagocytic Vesicle Virus Receptor Activity Symbiont Entry Into Host Cell Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-matrix Adhesion Actomyosin Structure Organization Cell-substrate Adhesion Integrin Binding Biological Process Involved In Interaction With Host Receptor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Actin Filament Organization Actin Cytoskeleton Organization Signaling Receptor Binding Actin Filament-based Process Focal Adhesion
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