PTGS1 and NCL

Number of citations of the paper that reports this interaction (PMID 17320986)
3

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		PTGS1	NCL
Gene Name		prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	nucleolin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cell Cortex Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Heme Binding Metal Ion Binding Dioxygenase Activity	Nucleotide Binding RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Regulation Of Cell Proliferation Small Molecule Metabolic Process Oxidation-reduction Process	Angiogenesis Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins COX reactions Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		gamma-Homolinolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Antrafenine Antipyrine Tiaprofenic acid O-Acetylserine Hyperforin 2-(1,1\'-Biphenyl-4-Yl)Propanoic Acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic Acid Beta-D-Glucose Beta-D-Mannose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Alpha-D-Mannose Heme Acetic Acid Salicyloyl-Amino-Ester P-(2\'-Iodo-5\'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic Acid Arachidonic Acid Dipyrone Lornoxicam Nepafenac 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE Triflusal
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		3 interactors: NCL NUCB1 PTGIS	48 interactors: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CSNK2A1 CSNK2A2 ERG ETS1 FMR1 GRB2 GZF1 GZMA H2AFX HIST1H1C HIST2H2AC HIST2H2BE HIST3H3 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PTGS1 S100A11 SREK1 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689
Entrez ID		5742	4691
HPRD ID		07518	01245
Ensembl ID		ENSG00000095303
Uniprot IDs		B4E2S5 P23219	B3KM80 P19338 Q9BQ02
PDB IDs			2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Nicotinamide Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Alkaloid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Cyclooxygenase Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Transcription From RNA Polymerase I Promoter Prostaglandin Biosynthetic Process Regulation Of Execution Phase Of Apoptosis Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Response To Interleukin-6 Negative Regulation Of Reactive Oxygen Species Metabolic Process Icosanoid Biosynthetic Process NAD Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Cellular Response To Interleukin-1 Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Arachidonic Acid Metabolic Process Response To Interleukin-1 Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Icosanoid Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Unsaturated Fatty Acid Metabolic Process Negative Regulation Of Inflammatory Response Cellular Response To Oxygen Levels Vitamin Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Long-chain Fatty Acid Metabolic Process Positive Regulation Of Angiogenesis Fatty Acid Biosynthetic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process	Chromosome Organization DNA Conformation Change Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Chromatin Organization Response To Stimulus Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA Packaging Cellular Response To Stimulus Developmental Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Regulation Of Apoptotic Process Chromatin Assembly Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Cell Death Chromatin Assembly Or Disassembly Response To Stress Mitotic Cell Cycle Checkpoint Regulation Of Cell Proliferation DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Aging Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process RNA Biosynthetic Process Cellular Senescence Double-strand Break Repair Protein Complex Assembly DNA Damage Checkpoint Cell Cycle Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle Process
Tagcloud ?		5p blockade centres coincided dendritic fdc fl follicles follicular gc germinal il6 ltbetar lymphoid lymphotoxin micrornas mir mmu nucleotides plausible repressing retain rnas select spleen stromal surfaces tlr4 yb	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Difference) ?		5p blockade centres coincided dendritic fdc fl follicles follicular gc germinal il6 ltbetar lymphoid lymphotoxin micrornas mir mmu nucleotides plausible repressing retain rnas select spleen stromal surfaces tlr4 yb	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Intersection) ?