PTGS1

Description		prostaglandin-endoperoxide synthase 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuron Projection Extracellular Exosome
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Population Proliferation Cellular Oxidant Detoxification
Pathways		COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin (+)-2-(4-biphenyl)propionic acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Nitroaspirin Bufexamac Bendazac Acemetacin Medical Cannabis Nabiximols
Diseases
GWAS		Glomerular filtration rate in chronic kidney disease ( 26420894) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		3 interacting genes: NCL NUCB1 PTGIS
Entrez ID		5742
HPRD ID		07518
Ensembl ID		ENSG00000095303
Uniprot IDs		A0A087X296 P23219
PDB IDs		6Y3C
Enriched GO Terms of Interacting Partners?		Macropinosome Membrane Telomeric DNA Binding MRNA 5'-UTR Binding Response To Peptide Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I PH Domain Binding Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of MRNA Splicing, Via Spliceosome Response To Cytokine Cellular Response To Cytokine Stimulus Insulin Receptor Substrate Binding DNA Topoisomerase Binding G-protein Alpha-subunit Binding Positive Regulation Of Execution Phase Of Apoptosis Decidualization Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Purine-containing Compound Salvage Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway NAD+ Biosynthetic Process Response To Interleukin-6 Prostaglandin-I Synthase Activity Pyridine Nucleotide Biosynthetic Process Hydroperoxy Icosatetraenoate Dehydratase Activity NAD+ Biosynthetic Process Via The Salvage Pathway Purine Nucleotide Salvage Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Prostanoid Metabolic Process Positive Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase I NAD+ Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Cellular Response To Insulin Stimulus Response To Epidermal Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Interleukin-1 Cornified Envelope Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Regulation Of Nitric Oxide Biosynthetic Process Monooxygenase Activity Regulation Of Nitric Oxide Metabolic Process
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