PTGS1 and NUCB1

Number of citations of the paper that reports this interaction (PMID 8643612)
15

Data Source:
HPRD (in vitro, two hybrid)

		PTGS1	NUCB1
Gene Name		prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	nucleobindin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Heme Binding Metal Ion Binding Dioxygenase Activity	DNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Regulation Of Cell Proliferation Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins COX reactions Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		gamma-Homolinolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Antrafenine Antipyrine Tiaprofenic acid O-Acetylserine Hyperforin 2-(1,1\'-Biphenyl-4-Yl)Propanoic Acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic Acid Beta-D-Glucose Beta-D-Mannose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Alpha-D-Mannose Heme Acetic Acid Salicyloyl-Amino-Ester P-(2\'-Iodo-5\'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic Acid Arachidonic Acid Dipyrone Lornoxicam Nepafenac 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE Triflusal
Diseases
GWAS
Protein-Protein Interactions		3 interactors: NCL NUCB1 PTGIS	15 interactors: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PTGS1 PTGS2 RBL1 REL SET XPO1
Entrez ID		5742	4924
HPRD ID		07518	03205
Ensembl ID		ENSG00000095303	ENSG00000104805
Uniprot IDs		B4E2S5 P23219	A8K7Q1 Q02818
PDB IDs			1SNL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Nicotinamide Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Alkaloid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Cyclooxygenase Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Transcription From RNA Polymerase I Promoter Prostaglandin Biosynthetic Process Regulation Of Execution Phase Of Apoptosis Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Response To Interleukin-6 Negative Regulation Of Reactive Oxygen Species Metabolic Process Icosanoid Biosynthetic Process NAD Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Cellular Response To Interleukin-1 Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Arachidonic Acid Metabolic Process Response To Interleukin-1 Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Icosanoid Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Unsaturated Fatty Acid Metabolic Process Negative Regulation Of Inflammatory Response Cellular Response To Oxygen Levels Vitamin Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Long-chain Fatty Acid Metabolic Process Positive Regulation Of Angiogenesis Fatty Acid Biosynthetic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Response To Organic Substance Platelet Activation Regulation Of Adenylate Cyclase Activity Cell Cycle Regulation Of Cyclase Activity Response To Drug Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Cyclooxygenase Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Response To Stimulus Response To Stress Signaling Prostaglandin Biosynthetic Process Cell Communication Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Lyase Activity Blood Coagulation Hemostasis Prostaglandin Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Regulation Of Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Genetic Imprinting Regulation Of Calcium Ion Transport Response To Transforming Growth Factor Beta Negative Regulation Of Nucleotide Metabolic Process Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus
Tagcloud ?		5p blockade centres coincided dendritic fdc fl follicles follicular gc germinal il6 ltbetar lymphoid lymphotoxin micrornas mir mmu nucleotides plausible repressing retain rnas select spleen stromal surfaces tlr4 yb
Tagcloud (Difference) ?		5p blockade centres coincided dendritic fdc fl follicles follicular gc germinal il6 ltbetar lymphoid lymphotoxin micrornas mir mmu nucleotides plausible repressing retain rnas select spleen stromal surfaces tlr4 yb
Tagcloud (Intersection) ?