USP30

Description		ubiquitin specific peptidase 30
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Autophagy Of Mitochondrion Pexophagy Proteolysis Mitochondrial Fusion Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Negative Regulation Of Mitophagy
Pathways		Ub-specific processing proteases Pexophagy
Drugs
Diseases
GWAS		Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		6 interacting genes: PAICS POLG PRKN RHBDD2 UBB UBC
Entrez ID		84749
HPRD ID		15633
Ensembl ID		ENSG00000135093
Uniprot IDs		B3KUS5 Q70CQ3
PDB IDs		5OHK 5OHN 5OHP 8D0A 8D1T
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Protein Ubiquitination Negative Regulation Of Intralumenal Vesicle Formation Modification-dependent Protein Catabolic Process Regulation Of Mitochondrial Membrane Potential Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin ERAD Pathway Positive Regulation Of Protein Ubiquitination Mitochondrion Localization Proteolysis Macromolecule Catabolic Process Mitochondrion Regulation Of Signal Transduction By P53 Class Mediator DNA Replication Proofreading Mitochondrial Chromosome Gamma DNA Polymerase Complex Endocytic Vesicle Membrane Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Protein Modification By Small Protein Conjugation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lyase Activity Lewy Body Regulation Of Spontaneous Synaptic Transmission Regulation Of Proteasomal Protein Catabolic Process Type 2 Mitophagy Post-translational Protein Modification Regulation Of Protein Ubiquitination
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