RCN3 and SUFU

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		RCN3	SUFU
Gene Name		reticulocalbin 3, EF-hand calcium binding domain	suppressor of fused homolog (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	Calcium Ion Binding Protein Binding	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Hematological and biochemical traits ( 20139978)	Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: HID1 KLHL42 MBD3 MKNK1 PACRGL PCSK6 PRUNE2 STAT6 SUFU	26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764
Entrez ID		57333	51684
HPRD ID		17962	06124
Ensembl ID		ENSG00000142552	ENSG00000107882
Uniprot IDs		Q96D15	Q9UMX1
PDB IDs			1M1L
Enriched GO Terms of Interacting Partners?		Response To Brefeldin A Determination Of Left/right Symmetry Determination Of Bilateral Symmetry T-helper 1 Cell Lineage Commitment Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Positive Regulation Of Isotype Switching To IgE Isotypes Interleukin-4-mediated Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Negative Regulation Of Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Methylation-dependent Chromatin Silencing T-helper Cell Lineage Commitment Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning T-helper 1 Cell Differentiation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cell Fate Commitment Negative Regulation Of Type 2 Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Ventral Spinal Cord Interneuron Specification Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Embryo Development Cellular Response To Reactive Nitrogen Species Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Isotype Switching T Cell Lineage Commitment Ventral Spinal Cord Interneuron Fate Commitment Response To Organic Substance Anterior/posterior Axis Specification, Embryo Ventral Spinal Cord Interneuron Differentiation Positive T Cell Selection T-helper 1 Type Immune Response Cytoplasmic Sequestering Of Transcription Factor T-helper Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud ?		advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting	beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Difference) ?		advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting	beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Intersection) ?