RCN3 and STAT6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RCN3	STAT6
Gene Name		reticulocalbin 3, EF-hand calcium binding domain	signal transducer and activator of transcription 6, interleukin-4 induced
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways			Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS		Hematological and biochemical traits ( 20139978)	Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		9 interactors: HID1 KLHL42 MBD3 MKNK1 PACRGL PCSK6 PRUNE2 STAT6 SUFU	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		57333	6778
HPRD ID		17962	03302
Ensembl ID		ENSG00000142552	ENSG00000166888
Uniprot IDs		Q96D15	A8K4S9 B4DQB3 P42226
PDB IDs			1OJ5
Enriched GO Terms of Interacting Partners?		Response To Brefeldin A Determination Of Left/right Symmetry Determination Of Bilateral Symmetry T-helper 1 Cell Lineage Commitment Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Positive Regulation Of Isotype Switching To IgE Isotypes Interleukin-4-mediated Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Negative Regulation Of Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Methylation-dependent Chromatin Silencing T-helper Cell Lineage Commitment Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning T-helper 1 Cell Differentiation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cell Fate Commitment Negative Regulation Of Type 2 Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Ventral Spinal Cord Interneuron Specification Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Embryo Development Cellular Response To Reactive Nitrogen Species Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Isotype Switching T Cell Lineage Commitment Ventral Spinal Cord Interneuron Fate Commitment Response To Organic Substance Anterior/posterior Axis Specification, Embryo Ventral Spinal Cord Interneuron Differentiation Positive T Cell Selection T-helper 1 Type Immune Response Cytoplasmic Sequestering Of Transcription Factor T-helper Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?		advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?		advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?