RCN3 and PCSK6

Number of citations of the paper that reports this interaction (PubMedID 16433634)
32

Data Source:
HPRD (in vivo)

		RCN3	PCSK6
Description		reticulocalbin 3	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding
	Biological Process	Protein Secretion Positive Regulation Of Peptidase Activity Protein Transport Collagen Biosynthetic Process ERAD Pathway Surfactant Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Homeostasis Lung Epithelium Development	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling
Pathways			Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Fructosamine levels ( 29844224 34753797) Height ( 31562340) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean spheric corpuscular volume ( 32888494) Schizophrenia ( 25056061) Total glycated albumin levels ( 29844224)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		15 interacting genes: DNAAF19 EZH2 HID1 KLHL42 MBD3 MKNK1 MYO15B NAA10 PACRGL PCSK6 PDE4B PRUNE2 STAT6 SUFU ZNF417	7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441
Entrez ID		57333	5046
HPRD ID		17962	01329
Ensembl ID		ENSG00000142552	ENSG00000140479
Uniprot IDs		Q96D15	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?		Determination Of Bilateral Symmetry Determination Of Left/right Symmetry	Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process
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