PTGDS and HK2

Number of citations of the paper that reports this interaction (PubMedID 11068878)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PTGDS	HK2
Description		prostaglandin D2 synthase	hexokinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Membrane Sarcoplasmic Reticulum
	Molecular Function	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Isomerase Activity Small Molecule Binding	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Gene Expression Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep Prostanoid Biosynthetic Process Response To Glucocorticoid Negative Regulation Of Male Germ Cell Proliferation	Response To Hypoxia Intracellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Metabolic Process Organophosphate Metabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of D-glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process Positive Regulation Of Type 2 Mitophagy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation	Glycolysis
Drugs		Vitamin A
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589) Keratoconus ( 33649486)	Femoral neck bone geometry ( 22087292)
Interacting Genes		23 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR GGA3 HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2	10 interacting genes: ENO1 MAGEA12 PRKCE PROM1 PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17
Entrez ID		5730	3099
HPRD ID		08904	03080
Ensembl ID		ENSG00000107317	ENSG00000159399
Uniprot IDs		A0A024R8G3 P41222	E9PB90 P52789
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9 8HTA	2NZT 5HEX 5HFU 5HG1
Enriched GO Terms of Interacting Partners?		Regulation Of Macroautophagy Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Hexokinase Activity Glucokinase Activity Fructokinase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Prostaglandin E Receptor Activity Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Nitric-oxide Synthase Regulator Activity D1 Dopamine Receptor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Catabolic Process Excitatory Postsynaptic Potential D-glucose Binding Catabolic Process Regulation Of Autophagy Regulation Of Protein Catabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor Establishment Of Protein Localization To Mitochondrion Response To UV-A Enzyme Binding Fructose 6-phosphate Metabolic Process Positive Regulation Of Protein Catabolic Process Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Identical Protein Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Postsynaptic Membrane Potential Response To Alcohol Macromolecule Catabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Peptidyl-serine Phosphorylation Glycolytic Process Through Glucose-6-phosphate Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Keratin Filament Positive Regulation Of DNA Metabolic Process Positive Regulation Of Protein Metabolic Process Ficolin-1-rich Granule Lumen Positive Regulation Of Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway	Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Perinuclear Region Of Cytoplasm Cellular Response To Oxygen Levels Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Hypoxia Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Store-operated Calcium Channel Activity Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Response To Oxygen Levels Endoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Prominosome Glomerular Parietal Epithelial Cell Differentiation Autophagosome Nuclear Proteasome Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Monoatomic Ion Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Response To Ethanol Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process White Fat Cell Proliferation Positive Regulation Of Mucus Secretion Regulation Of Male Germ Cell Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosolic Proteasome Complex Regulation Of Cellular Response To Stress Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Germ Cell Proliferation
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