PTGDS and PTGFR

Number of citations of the paper that reports this interaction (PMID 8300593)
31

Data Source:
HPRD (in vivo)

		PTGDS	PTGFR
Gene Name		prostaglandin D2 synthase 21kDa (brain)	prostaglandin F receptor (FP)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Prostaglandin-D Synthase Activity Transporter Activity Retinoid Binding Fatty Acid Binding	Prostaglandin F Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Transport Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Glucocorticoid	G-protein Coupled Receptor Signaling Pathway Parturition Positive Regulation Of Cell Proliferation Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Travoprost Latanoprost Bimatoprost Dinoprost Tromethamine Tafluprost
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589)	Bipolar disorder ( 22182935)
Protein-Protein Interactions		17 interactors: ARR3 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 MLH1 PTGER1 PTGER2 PTGFR SHBG	4 interactors: PTGDS PTGER1 PTGER2 PTGES2
Entrez ID		5730	5737
HPRD ID		08904	08988
Ensembl ID		ENSG00000107317	ENSG00000122420
Uniprot IDs		P41222	P43088
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Response To External Stimulus Cellular Response To Prostaglandin Stimulus Adult Behavior Single-organism Behavior Cellular Response To Acid Chemical Glucose 6-phosphate Metabolic Process Regulation Of Nitric-oxide Synthase Activity Hexose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Fatty Acid Locomotory Behavior Response To Abiotic Stimulus Behavior Adult Walking Behavior Monosaccharide Metabolic Process Signaling Catabolic Process G-protein Coupled Receptor Signaling Pathway Neurological System Process Cell Communication Regulation Of Nitric Oxide Biosynthetic Process Carbohydrate Phosphorylation Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Negative Regulation Of Eosinophil Extravasation Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Primary Spermatocyte Growth Cell Activation Regulation Of Reactive Oxygen Species Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of Synaptic Transmission Response To Lipopolysaccharide Response To Fatty Acid Reproductive Process Cellular Response To Mechanical Stimulus Glucose Transport Anatomical Structure Development Cellular Glucose Homeostasis Receptor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Response To Molecule Of Bacterial Origin Regulation Of Oxidoreductase Activity Hexose Transport Multicellular Organismal Reproductive Process Branched-chain Amino Acid Biosynthetic Process Vestibular Nucleus Development	Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Negative Regulation Of Eosinophil Extravasation Response To Lipid Fatty Acid Biosynthetic Process Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus Response To Bacterium Cyclooxygenase Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Negative Regulation Of Leukocyte Migration Response To Organic Substance T-helper Cell Differentiation Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Lipid Metabolic Process Alpha-beta T Cell Differentiation Carboxylic Acid Metabolic Process Regulation Of Stress Fiber Assembly Arachidonic Acid Metabolic Process Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Cellular Response To Mechanical Stimulus Organic Acid Metabolic Process G-protein Coupled Receptor Signaling Pathway JNK Cascade Positive Regulation Of Cytokine Secretion Lipid Metabolic Process Positive Regulation Of Inflammatory Response
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases