PTGDS and PTGER1

Number of citations of the paper that reports this interaction (PMID 8253813)
40

Data Source:
HPRD (in vivo)

		PTGDS	PTGER1
Gene Name		prostaglandin D2 synthase 21kDa (brain)	prostaglandin E receptor 1 (subtype EP1), 42kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Prostaglandin-D Synthase Activity Transporter Activity Retinoid Binding Fatty Acid Binding	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Transport Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Glucocorticoid	G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Bupivacaine Carboprost Tromethamine Alprostadil Bimatoprost Dinoprostone Iloprost
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589)
Protein-Protein Interactions		17 interactors: ARR3 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 MLH1 PTGER1 PTGER2 PTGFR SHBG	5 interactors: ADRB2 PTGDS PTGER3 PTGES PTGFR
Entrez ID		5730	5731
HPRD ID		08904	08903
Ensembl ID		ENSG00000107317	ENSG00000160951
Uniprot IDs		P41222	P34995
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Response To External Stimulus Cellular Response To Prostaglandin Stimulus Adult Behavior Single-organism Behavior Cellular Response To Acid Chemical Glucose 6-phosphate Metabolic Process Regulation Of Nitric-oxide Synthase Activity Hexose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Fatty Acid Locomotory Behavior Response To Abiotic Stimulus Behavior Adult Walking Behavior Monosaccharide Metabolic Process Signaling Catabolic Process G-protein Coupled Receptor Signaling Pathway Neurological System Process Cell Communication Regulation Of Nitric Oxide Biosynthetic Process Carbohydrate Phosphorylation Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Negative Regulation Of Eosinophil Extravasation Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Primary Spermatocyte Growth Cell Activation Regulation Of Reactive Oxygen Species Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of Synaptic Transmission Response To Lipopolysaccharide Response To Fatty Acid Reproductive Process Cellular Response To Mechanical Stimulus Glucose Transport Anatomical Structure Development Cellular Glucose Homeostasis Receptor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Response To Molecule Of Bacterial Origin Regulation Of Oxidoreductase Activity Hexose Transport Multicellular Organismal Reproductive Process Branched-chain Amino Acid Biosynthetic Process Vestibular Nucleus Development	Heat Generation Cyclooxygenase Pathway Response To Lipid Prostaglandin Biosynthetic Process Temperature Homeostasis Prostaglandin Metabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Bacterium Acute Inflammatory Response Icosanoid Metabolic Process Response To External Stimulus Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Response To Other Organism Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Biotic Stimulus Fatty Acid Biosynthetic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Response To Organic Substance Fever Generation Multicellular Organismal Homeostasis G-protein Coupled Receptor Signaling Pathway Cellular Response To Prostaglandin D Stimulus Diet Induced Thermogenesis Fatty Acid Metabolic Process Positive Regulation Of Fever Generation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Fever Generation Positive Regulation Of Heat Generation Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Dietary Excess Parturition Cellular Response To Prostaglandin Stimulus Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Response To Stimulus
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases	acutely autacoids bdkrb2 bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin prostaglandin prostaglandins ptgs ptgs1 ptgs2 ptgss pvd9902 reportedly sc sulprostone vas
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr reaches slco2a synthases	acutely autacoids bdkrb2 bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin prostaglandin prostaglandins ptgs ptgs1 ptgss pvd9902 reportedly sc sulprostone vas
Tagcloud (Intersection) ?		ptgs2