PTGDS and PTGER2

Number of citations of the paper that reports this interaction (PMID 8163486)
24

Data Source:
HPRD (in vivo)

		PTGDS	PTGER2
Gene Name		prostaglandin D2 synthase 21kDa (brain)	prostaglandin E receptor 2 (subtype EP2), 53kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Prostaglandin-D Synthase Activity Transporter Activity Retinoid Binding Fatty Acid Binding	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Transport Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Glucocorticoid	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cellular Response To Prostaglandin E Stimulus
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Alprostadil Dinoprostone Misoprostol
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589)
Protein-Protein Interactions		17 interactors: ARR3 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 MLH1 PTGER1 PTGER2 PTGFR SHBG	3 interactors: PTGDS PTGES PTGFR
Entrez ID		5730	5732
HPRD ID		08904	08905
Ensembl ID		ENSG00000107317	ENSG00000125384
Uniprot IDs		P41222	P43116
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Response To External Stimulus Cellular Response To Prostaglandin Stimulus Adult Behavior Single-organism Behavior Cellular Response To Acid Chemical Glucose 6-phosphate Metabolic Process Regulation Of Nitric-oxide Synthase Activity Hexose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Fatty Acid Locomotory Behavior Response To Abiotic Stimulus Behavior Adult Walking Behavior Monosaccharide Metabolic Process Signaling Catabolic Process G-protein Coupled Receptor Signaling Pathway Neurological System Process Cell Communication Regulation Of Nitric Oxide Biosynthetic Process Carbohydrate Phosphorylation Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Negative Regulation Of Eosinophil Extravasation Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Primary Spermatocyte Growth Cell Activation Regulation Of Reactive Oxygen Species Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of Synaptic Transmission Response To Lipopolysaccharide Response To Fatty Acid Reproductive Process Cellular Response To Mechanical Stimulus Glucose Transport Anatomical Structure Development Cellular Glucose Homeostasis Receptor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Response To Molecule Of Bacterial Origin Regulation Of Oxidoreductase Activity Hexose Transport Multicellular Organismal Reproductive Process Branched-chain Amino Acid Biosynthetic Process Vestibular Nucleus Development	Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Lipid Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Response To Bacterium Response To Organic Substance Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Parturition Cellular Response To Prostaglandin Stimulus Response To Other Organism Response To Biotic Stimulus Response To Organic Cyclic Compound Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To Fatty Acid Organic Acid Metabolic Process Lipid Metabolic Process Response To Fatty Acid Acute Inflammatory Response Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Circadian Rhythm Response To Calcium Ion Response To Retinoic Acid Response To External Stimulus Second-messenger-mediated Signaling Response To Glucocorticoid Response To Corticosteroid Cellular Response To Acid Chemical Regulation Of Behavior Small Molecule Metabolic Process
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases	appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases	appeared deltadeltact diestrus ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Intersection) ?		endometrium