PTGDS and PTGER2

Number of citations of the paper that reports this interaction (PubMedID 8163486)
0

Data Source:
HPRD (in vivo)

		PTGDS	PTGER2
Description		prostaglandin D2 synthase	prostaglandin E receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Isomerase Activity Small Molecule Binding	G Protein-coupled Receptor Activity Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Gene Expression Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep Prostanoid Biosynthetic Process Response To Glucocorticoid Negative Regulation Of Male Germ Cell Proliferation	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nematode Response To Lipopolysaccharide Response To Progesterone Regulation Of Cell Population Proliferation Cellular Response To Prostaglandin E Stimulus
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation	Prostanoid ligand receptors G alpha (s) signalling events
Drugs		Vitamin A	Treprostinil Alprostadil Dinoprostone Misoprostol Trichostatin A Gemeprost Limaprost Omidenepag isopropyl Rivenprost
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589) Keratoconus ( 33649486)
Interacting Genes		23 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR GGA3 HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2	3 interacting genes: PTGDS PTGES PTGFR
Entrez ID		5730	5732
HPRD ID		08904	08905
Ensembl ID		ENSG00000107317	ENSG00000125384
Uniprot IDs		A0A024R8G3 P41222	P43116
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9 8HTA	7CX2 7CX3 7CX4
Enriched GO Terms of Interacting Partners?		Regulation Of Macroautophagy Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Hexokinase Activity Glucokinase Activity Fructokinase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Prostaglandin E Receptor Activity Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Nitric-oxide Synthase Regulator Activity D1 Dopamine Receptor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Catabolic Process Excitatory Postsynaptic Potential D-glucose Binding Catabolic Process Regulation Of Autophagy Regulation Of Protein Catabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor Establishment Of Protein Localization To Mitochondrion Response To UV-A Enzyme Binding Fructose 6-phosphate Metabolic Process Positive Regulation Of Protein Catabolic Process Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Identical Protein Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Postsynaptic Membrane Potential Response To Alcohol Macromolecule Catabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Peptidyl-serine Phosphorylation Glycolytic Process Through Glucose-6-phosphate Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Keratin Filament Positive Regulation Of DNA Metabolic Process Positive Regulation Of Protein Metabolic Process Ficolin-1-rich Granule Lumen Positive Regulation Of Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway	Prostaglandin-D Synthase Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin F Receptor Activity Isomerase Activity Negative Regulation Of Male Germ Cell Proliferation Prostaglandin-E Synthase Activity Carboxylic Acid Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Cellular Response To Prostaglandin D Stimulus Regulation Of Fever Generation Parturition Retinoid Binding Glutathione Binding Small Molecule Biosynthetic Process Nuclear Envelope Lumen Monocarboxylic Acid Metabolic Process Positive Regulation Of Prostaglandin Secretion Lipid Biosynthetic Process Positive Regulation Of Icosanoid Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Glutathione Peroxidase Activity Positive Regulation Of Fatty Acid Transport Response To Hormone Regulation Of Circadian Sleep/wake Cycle Mast Cell Degranulation Small Molecule Binding Cellular Response To Prostaglandin Stimulus Negative Regulation Of Cell Population Proliferation Fatty Acid Binding Organic Acid Metabolic Process Perinuclear Region Of Cytoplasm Carboxylic Acid Metabolic Process Glutathione Transferase Activity Regulation Of Fatty Acid Transport Rough Endoplasmic Reticulum Response To Lipid Leukocyte Degranulation Sensory Perception Of Pain Regulation Of Acute Inflammatory Response
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