PTGDS and BCAT2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PTGDS	BCAT2
Gene Name		prostaglandin D2 synthase 21kDa (brain)	branched chain amino-acid transaminase 2, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Prostaglandin-D Synthase Activity Transporter Activity Retinoid Binding Fatty Acid Binding	Branched-chain-amino-acid Transaminase Activity L-leucine Transaminase Activity L-valine Transaminase Activity L-isoleucine Transaminase Activity
	Biological Process	Prostaglandin Biosynthetic Process Transport Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Glucocorticoid	Isoleucine Catabolic Process Leucine Metabolic Process Valine Metabolic Process Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Regulation Of Hormone Levels Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Branched-chain amino acid catabolism Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Glutamic Acid L-Leucine L-Isoleucine Pyridoxamine-5\'-Phosphate N-[O-Phosphono-Pyridoxyl]-Isoleucine Alpha-ketoisovalerate
Diseases
GWAS		Beta-trace protein levels ( 23328707) Corneal structure ( 23291589)
Protein-Protein Interactions		17 interactors: ARR3 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 MLH1 PTGER1 PTGER2 PTGFR SHBG	4 interactors: ALDOA APP CREB3 PTGDS
Entrez ID		5730	587
HPRD ID		08904	00217
Ensembl ID		ENSG00000107317	ENSG00000105552
Uniprot IDs		P41222	O15382
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO	1EKF 1EKP 1EKV 1KT8 1KTA 2A1H 2HDK 2HG8 2HGW 2HGX 2HHF
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Response To External Stimulus Cellular Response To Prostaglandin Stimulus Adult Behavior Single-organism Behavior Cellular Response To Acid Chemical Glucose 6-phosphate Metabolic Process Regulation Of Nitric-oxide Synthase Activity Hexose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Fatty Acid Locomotory Behavior Response To Abiotic Stimulus Behavior Adult Walking Behavior Monosaccharide Metabolic Process Signaling Catabolic Process G-protein Coupled Receptor Signaling Pathway Neurological System Process Cell Communication Regulation Of Nitric Oxide Biosynthetic Process Carbohydrate Phosphorylation Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Negative Regulation Of Eosinophil Extravasation Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Primary Spermatocyte Growth Cell Activation Regulation Of Reactive Oxygen Species Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of Synaptic Transmission Response To Lipopolysaccharide Response To Fatty Acid Reproductive Process Cellular Response To Mechanical Stimulus Glucose Transport Anatomical Structure Development Cellular Glucose Homeostasis Receptor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Response To Molecule Of Bacterial Origin Regulation Of Oxidoreductase Activity Hexose Transport Multicellular Organismal Reproductive Process Branched-chain Amino Acid Biosynthetic Process Vestibular Nucleus Development	Platelet Degranulation Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Synaptic Growth At Neuromuscular Junction Release From Viral Latency Regulation Of Behavior Platelet Activation Collateral Sprouting In Absence Of Injury Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Deacetylase Activity Axon Choice Point Recognition Exocytosis Neuron Remodeling Establishment Of Viral Latency Positive Regulation Of Monocyte Chemotaxis Blood Coagulation Hemostasis Regulation Of Monocyte Chemotaxis Secretion By Cell Positive Regulation Of Defense Response To Virus By Host Cyclooxygenase Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Induction Of Positive Chemotaxis Cellular Copper Ion Homeostasis Fructose Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Small Molecule Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Wound Healing Chemotaxis Prostaglandin Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Sequestering Of Protein Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Muscle Cell Cellular Homeostasis Cell Activation Cellular Homeostasis Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Prostaglandin Metabolic Process
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?