MAGI3 and PTPRB

Number of citations of the paper that reports this interaction (PubMedID 12615970)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAGI3	PTPRB
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	protein tyrosine phosphatase receptor type B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction	Plasma Membrane Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane
	Molecular Function	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process	Angiogenesis Osteoblast Differentiation Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Glial Cell Migration Dephosphorylation Developmental Process Negative Regulation Of Osteoblast Differentiation
Pathways			Neutrophil degranulation
Drugs			{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2	11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		260425	5787
HPRD ID		11290	01474
Ensembl ID		ENSG00000081026	ENSG00000127329
Uniprot IDs		Q5TCQ9	F8VU56 P23467 Q86VA4
PDB IDs		3SOE	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X 8JBN 8JBY
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway	Cell Adhesion Protein Phosphatase Binding Regulation Of Cellular Component Organization Cell-cell Junction Anchoring Junction Cell Junction Cell-cell Adhesion Bicellular Tight Junction Cell-cell Adhesion Mediator Activity Regulation Of Endothelial Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Mechanical Stimulus Receptor Complex Cell Junction Organization Basal Plasma Membrane Developmental Process Animal Organ Development Membrane Anatomical Structure Morphogenesis Synapse Organization Cell Junction Assembly Glutamatergic Synapse Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Rho Protein Signal Transduction Endothelial Cell Morphogenesis Regulation Of Developmental Process Cell Surface Cadherin Binding Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activator Activity Response To Estradiol Morphogenesis Of An Epithelium Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Cell-cell Junction Assembly Protein Localization To Cell-cell Junction Positive Regulation Of Homotypic Cell-cell Adhesion Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Tissue Morphogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Anatomical Structure Formation Involved In Morphogenesis
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