MAGI3 and FZD4

Number of citations of the paper that reports this interaction (PMID 15195140)
16

Data Source:
HPRD (in vivo, two hybrid)

		MAGI3	FZD4
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 3	frizzled class receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Tight Junction Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Frizzled Binding Protein Binding ATP Binding Protein Complex Scaffold	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Viral Process Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Nucleotide Phosphorylation	Vasculogenesis G-protein Coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Neuron Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Progesterone Secretion Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN WNT5A-dependent internalization of FZD4 Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: ADRB1 BAI1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB TGFA TNK2 VANGL2	7 interactors: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3
Entrez ID		260425	8322
HPRD ID		11290	05203
Ensembl ID		ENSG00000081026	ENSG00000174804
Uniprot IDs		Q5TCQ9	Q9ULV1
PDB IDs		3SOE
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Developmental Process Cell Morphogenesis Involved In Differentiation Neuron Differentiation Anatomical Structure Morphogenesis Cell Differentiation Generation Of Neurons System Development Neurogenesis Signaling Negative Regulation Of Cell Adhesion Cell Communication Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Multicellular Organismal Development Axonogenesis Anatomical Structure Development Neuron Development Axon Development Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Non-canonical Wnt Signaling Pathway Signal Transduction Nervous System Development Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Projection Organization Locomotion Blood Vessel Morphogenesis Negative Regulation Of Cell-substrate Adhesion Regulation Of Phosphorylation Regulation Of Cellular Component Organization Neuron Projection Development Positive Regulation Of Phosphorylation Cardiovascular System Development Positive Regulation Of Protein Modification Process Blood Vessel Development Response To Stimulus Vasculature Development Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Wnt Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Multicellular Organismal Response To Stress Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Protein Localization To Membrane Protein Localization Nervous System Development Regulation Of Catalytic Activity Nucleotide Metabolic Process Cellular Protein Localization Regulation Of Phosphorus Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Signaling Cell Communication Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Organophosphate Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process System Development Positive Regulation Of JUN Kinase Activity Cellular Localization Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Sensory Perception Of Pain Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission Anatomical Structure Development Synaptic Transmission Positive Regulation Of Catalytic Activity Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam	ameliorating c181r c204r c204y coexpression confocal correctable culturing exit exudative fevr fifteen frizzled g36n g488d glycosylation h69y haploinsufficiency inability localizations m105t m105v misfolding missense p33s polyubiquitination subcellular trafficking vitreoretinopathy
Tagcloud (Difference) ?		aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam	ameliorating c181r c204r c204y coexpression confocal correctable culturing exit exudative fevr fifteen frizzled g36n g488d glycosylation h69y haploinsufficiency inability localizations m105t m105v misfolding missense p33s polyubiquitination subcellular trafficking vitreoretinopathy
Tagcloud (Intersection) ?