MAGI3 and GRIN2B

Number of citations of the paper that reports this interaction (PubMedID 10748157)
0

Data Source:
HPRD (two hybrid)

		MAGI3	GRIN2B
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	glutamate ionotropic receptor NMDA type subunit 2B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction	Cytoplasm Lysosome Endosome Late Endosome Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Cell Projection Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Negative Regulation Of Dendritic Spine Maintenance Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Haloperidol Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Taurine Milnacipran EVT-101 Lumateperone Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Esketamine Fluciclovine (18F)
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Anxiety ( 33859377) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Dietary fat liking ( 32516399) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Keratoconus ( 33649486) Major depressive disorder ( 23377640) Opioid dependence (time to event) ( 34124712) Ovarian reserve ( 22116950) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2	45 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 EGFR EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 RASGRF1 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		260425	2904
HPRD ID		11290	00697
Ensembl ID		ENSG00000081026	ENSG00000273079
Uniprot IDs		Q5TCQ9	A0A8D9PHB2 Q13224
PDB IDs		3SOE	5EWJ 5EWL 5EWM 7EU8 7KL0 7KL1 7KL2 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 8VUU 8VUV 9D37 9D38 9D39 9D3A 9D3B 9D3C
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway	Postsynaptic Density Neuron Projection Regulation Of Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Cellular Localization Plasma Membrane Cytosol Regulation Of Protein Localization Regulation Of Synaptic Plasticity Learning Or Memory Postsynaptic Density Membrane Synapse Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Plasma Membrane Cognition Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Localization To Cell Periphery Kinase Activity Protein Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Junction Positive Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Synaptic Transmission Signal Transduction Regulation Of Transport Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Glutamatergic Synapse Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Metal Ion Transport Protein Serine Kinase Activity Intracellular Signal Transduction Endocytic Vesicle Membrane ERBB Signaling Pathway System Process Regulation Of Monoatomic Ion Transport Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Positive Regulation Of Protein Localization MPP7-DLG1-LIN7 Complex
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