MAGI3 and NRCAM

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		MAGI3	NRCAM
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	neuronal cell adhesion molecule
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Axon Cell Projection Neuron Projection Axon Initial Segment Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process	Angiogenesis Neuron Migration Cell Adhesion Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Brain Development Intracellular Protein Localization Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Synapse Organization Cell-cell Adhesion Regulation Of Postsynapse Organization
Pathways			Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Blood protein levels ( 30072576) Coffee consumption ( 21876539) Diastolic blood pressure ( 27841878) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333) White matter hyperintensity burden ( 25663218)
Interacting Genes		24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2	11 interacting genes: ANK2 CNTN2 HSPA12A LCOR LNX1 MACF1 MAGI3 NFASC PTPRB RSPH1 VPS26C
Entrez ID		260425	4897
HPRD ID		11290	07207
Ensembl ID		ENSG00000081026	ENSG00000091129
Uniprot IDs		Q5TCQ9	A0A1S5UZH4 B7Z670 C9JYY6 Q14CA1 Q92823
PDB IDs		3SOE	1UEN 1UEY
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway	Node Of Ranvier Axon Initial Segment
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