PSMD9 and NCKIPSD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PSMD9	NCKIPSD
Description		proteasome 26S subunit, non-ATPase 9	NCK interacting protein with SH3 domain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex	Nucleus Nucleoplasm Cytosol Intermediate Filament Plasma Membrane COP9 Signalosome Postsynapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding BHLH Transcription Factor Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Arp2/3 Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Insulin Secretion Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Secretion Proteasome Regulatory Particle Assembly	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Regulation Of Postsynapse Assembly
Pathways		Proteasome assembly	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean platelet volume ( 24026423) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Urinary metabolites (H-NMR features) ( 24586186)	A body shape index ( 34021172) Anorexia nervosa ( 31308545) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		21 interacting genes: AHCYL1 BANP BRCA1 CCDC136 CEP85L CKS1B CSH1 ELSPBP1 GH1 HNRNPA1 MEOX2 NCKIPSD PSMC6 RIN3 SKP2 TCF3 TNIP2 TRAF2 TRIM39 TRIM42 YY1	42 interacting genes: ABI2 AKT1 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		5715	51517
HPRD ID		04394	09450
Ensembl ID		ENSG00000110801	ENSG00000213672
Uniprot IDs		O00233	Q9NZQ3
PDB IDs			6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Binding Immunoglobulin V(D)J Recombination CD40 Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding V(D)J Recombination Positive Regulation Of DNA Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway	Actin Filament Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Translational Initiation Actin Polymerization Or Depolymerization Cellular Component Assembly Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cytoskeletal Anchor Activity Actin Filament Polymerization Protein Polymerization Regulation Of Actin Cytoskeleton Organization Lamellipodium Assembly Vesicle Membrane Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Organization Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C Inhibitor Activity Cytoskeleton Organization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Organelle Organization Scaffold Protein Binding Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Protein-containing Complex Assembly Dendritic Spine Regulation Of Cellular Component Size Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress ERBB Signaling Pathway Positive Regulation Of Translation Insulin Receptor Signaling Pathway
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