PSMD9 and TRIM39

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PSMD9	TRIM39
Gene Name		proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	tripartite motif containing 39
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex	Mitochondrion Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding BHLH Transcription Factor Binding	Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Insulin Secretion Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome Regulatory Particle Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Apoptotic Process Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AHCYL1 BANP BRCA1 CCDC136 CKS1B CSH1 DCLRE1C ELSPBP1 NCKIPSD PSMC3 PSMC6 SKP2 TCF3 TNIP2 TRIM39 TRIM42 YY1	52 interactors: APP CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 KDM1A LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		5715	56658
HPRD ID		04394	09298
Ensembl ID		ENSG00000110801	ENSG00000204599
Uniprot IDs		O00233	Q9HCM9
PDB IDs			2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Protein Ubiquitination DNA Recombination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Catabolic Process Double-strand Break Repair Cell Cycle V(D)J Recombination Cellular Response To DNA Damage Stimulus DNA Damage Checkpoint Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Cell Death Death Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Mitotic Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Activation Of Innate Immune Response
Tagcloud ?		acetyltransferase adenoviral augment augments bridge cipitation coactivators coregulator e12 e1a e47 encompass gst h2 helix histidine homeodomain immunopre interrupts mutagenesis pdx pdz pull sequestration suppresses transcriptional transferase trichostatin unable	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Difference) ?		acetyltransferase adenoviral augment augments bridge cipitation coactivators coregulator e12 e1a e47 encompass gst h2 helix histidine homeodomain immunopre interrupts mutagenesis pdx pdz pull sequestration suppresses transcriptional transferase trichostatin unable	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Intersection) ?