ADCK1 and EXOC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADCK1	EXOC5
Description		aarF domain containing kinase 1	exocyst complex component 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Exocyst Cytoplasm Cytosol Midbody
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity	Protein Binding Small GTPase Binding
	Biological Process	Mitochondrion Organization Negative Regulation Of Mitochondrial Fusion Lipid Homeostasis Positive Regulation Of Cristae Formation	Mitotic Cytokinesis Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Protein Localization To Plasma Membrane Membrane Fission Vesicle Tethering Involved In Exocytosis Epithelial Cell Apoptotic Process Non-motile Cilium Assembly
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Cerebrospinal T-tau levels ( 28247064) Obsessive-compulsive disorder ( 30456828) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Resting heart rate ( 27798624)	Alcohol consumption ( 23743675) Chronotype ( 30696823) HDL cholesterol levels in HIV infection ( 33109212) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		2 interacting genes: EXOC5 RAB1A	41 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L C1orf216 CCDC102B CDH2 CREBBP CRYBB1 DEUP1 DNAAF4 EDRF1 ENO2 FGA FRMD6 HDDC3 HGS ICA1 IFT57 KIFC3 MAGEA3 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 THOC1 TNPO2 TTC23L TXLNB TXNL4A USP2
Entrez ID		57143	10640
HPRD ID		10630	07258
Ensembl ID		ENSG00000063761	ENSG00000070367
Uniprot IDs		Q86TW2	O00471
PDB IDs
Enriched GO Terms of Interacting Partners?		Secretion By Cell Organelle Localization Cilium Organization Cell Projection Assembly Cilium Assembly Golgi Vesicle Transport Plasma Membrane Bounded Cell Projection Assembly Growth Hormone Secretion Secretion Virion Assembly Vesicle Tethering Involved In Exocytosis Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Melanosome Localization Establishment Of Endothelial Intestinal Barrier Melanosome Localization Plasma Membrane Bounded Cell Projection Organization COPII-coated Vesicle Cargo Loading Melanosome Transport Pigment Granule Transport Organelle Assembly Exocyst Establishment Of Planar Polarity Pigment Granule Localization Vesicle Cargo Loading Vesicle Tethering Protein Transport Cell Projection Organization Vesicle Transport Along Microtubule Vesicle-mediated Transport Establishment Of Protein Localization Substrate Adhesion-dependent Cell Spreading Endothelial Cell Development Establishment Of Endothelial Barrier Epithelial Cell Apoptotic Process Membrane Fission Vesicle Docking Involved In Exocytosis Transport Vesicle Membrane Non-motile Cilium Assembly Vesicle Cytoskeletal Trafficking Positive Regulation Of Interleukin-8 Production Vesicle Docking Golgi To Plasma Membrane Transport Cellular Localization Mitotic Cytokinesis Peptide Hormone Secretion G Protein Activity Peptide Secretion Organelle Localization By Membrane Tethering Hormone Secretion Regulation Of Interleukin-8 Production	G Protein Activity GDP Binding Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Membrane GTPase Activity Early Endosome Membrane Regulation Of Endocytosis Insulin-responsive Compartment
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