CHMP1B and USP8

Number of citations of the paper that reports this interaction (PubMedID 35995394)
0

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		CHMP1B	USP8
Description		charged multivesicular body protein 1B	ubiquitin specific peptidase 8
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GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding MIT Domain Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus
Pathways			Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		19 interacting genes: CHMP1A CHMP4B CHMP5 CNOT10 KNSTRN MITD1 PICK1 RAB11A RASSF7 SNCA SNRNP200 SPAST SSRP1 STAMBP SUCLG1 USP54 USP8 VPS4A VPS4B	49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ
Entrez ID		57132	9101
HPRD ID		12106	04405
Ensembl ID		ENSG00000255112	ENSG00000138592
Uniprot IDs		Q7LBR1	A8K8N5 P40818
PDB IDs		3EAB 3JC1 4TXQ 4TXR 6E8G 6TZ4 6TZ5 6TZ9 8V2Q 8V2R 8V2S	1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A
Enriched GO Terms of Interacting Partners?		Cytokinetic Process Viral Budding Via Host ESCRT Complex Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Assembly Multivesicular Body Organization Viral Budding From Plasma Membrane Endosome Organization Cytoskeleton-dependent Cytokinesis Membrane Fission Mitotic Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Midbody Nuclear Membrane Organization Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Membrane Assembly Mitotic Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromosome Localization ESCRT III Complex Disassembly ESCRT Complex Disassembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Endosome Autophagosome Maturation Kinetochore Microtubule Protein-containing Complex Disassembly Viral Process Membrane Organization Regulation Of Mitotic Spindle Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Vesicle Organization Nuclear Pore Nucleus Organization Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization Multivesicular Body ESCRT III Complex Plasma Membrane Organization Amphisome Membrane Vesicle Fusion With Vacuole Lysosomal Transport Regulation Of Centrosome Duplication	Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody
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