CHMP1B and USP8

Number of citations of the paper that reports this interaction (PMID 17711858)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CHMP1B	USP8
Gene Name		charged multivesicular body protein 1B	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Cytosol Late Endosome Membrane Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Establishment Of Protein Localization Regulation Of Mitotic Spindle Assembly	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways			Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CHMP1A CHMP4B CHMP5 CNOT10 KNSTRN RAB11A RASSF7 SNRNP200 SPAST SSRP1 STAMBP SUCLG1 USP54 USP8 VPS4A VPS4B	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		57132	9101
HPRD ID		12106	04405
Ensembl ID		ENSG00000255112	ENSG00000138592
Uniprot IDs		Q7LBR1	P40818
PDB IDs		3EAB	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Cell Division Mitotic Sister Chromatid Segregation Metaphase Plate Congression Sister Chromatid Segregation Establishment Of Chromosome Localization Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cytokinesis Chromosome Segregation Regulation Of Mitotic Spindle Organization Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Mitotic Nuclear Division Regulation Of Microtubule-based Process Cell Cycle Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Nucleus Organization Regulation Of Centrosome Duplication Viral Budding Regulation Of Centrosome Cycle Establishment Of Organelle Localization Chromosome Organization Organelle Localization Endosomal Transport Virion Assembly Regulation Of Cell Cycle Process Regulation Of Cell Division Regulation Of Cytoskeleton Organization Endosome Organization Regulation Of Mitotic Nuclear Division Mitotic Cytokinesis Regulation Of Mitotic Cell Cycle Organelle Organization Viral Life Cycle Positive Regulation Of Viral Release From Host Cell Cellular Macromolecule Catabolic Process Positive Regulation Of Viral Process Regulation Of Organelle Organization Vacuolar Transport Regulation Of Cell Cycle Membrane Budding Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		aux1 auxin disorganized endosomal escrt gradients internalized lip5 lumenal meristems mislocalized multivesicular mvb mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		aux1 auxin disorganized endosomal escrt gradients internalized lip5 lumenal meristems mislocalized multivesicular mvb mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?