AVEN and APAF1

Number of citations of the paper that reports this interaction (PMID 10949025)
33

Data Source:
HPRD (two hybrid, in vivo)

		AVEN	APAF1
Gene Name		apoptosis, caspase activation inhibitor	apoptotic peptidase activating factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Endomembrane System Membrane	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs			Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APAF1 BCL2L1 SMURF1	18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1
Entrez ID		57099	317
HPRD ID		05588	03755
Ensembl ID		ENSG00000169857	ENSG00000120868
Uniprot IDs		Q9NQS1	O14727
PDB IDs			1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS
Enriched GO Terms of Interacting Partners?		Regulation Of Execution Phase Of Apoptosis Neuron Apoptotic Process Neuron Death Response To G1 DNA Damage Checkpoint Signaling Apoptotic Process In Bone Marrow Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Suppression By Virus Of Host Apoptotic Process Apoptotic Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Execution Phase Of Apoptosis Cellular Response To Virus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Modulation By Virus Of Host Process Regulation Of Signal Transduction Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Anoikis Positive Regulation Of Cell Death Cellular Response To Gamma Radiation Hepatocyte Apoptotic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Regulation Of Signaling Protein Localization To Cell Surface Receptor Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Mitochondrion Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Response To Biotic Stimulus Ectoderm Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Permeability Cellular Response To Alkaloid Regulation Of Membrane Permeability Protein Export From Nucleus Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Plasma Membrane Programmed Cell Death	Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress
Tagcloud ?		bid chemicals chiral cideb configuration ddd ddt detrimental discern disturbing ecotoxicological effort enantiomer enantioselective enantioselectivity enantiospecific expended fate formulated impede metabolite metabolites pc12 pollutants pops preferential stereostructural stereostructure stereostructures	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Difference) ?		bid chemicals chiral cideb configuration ddd ddt detrimental discern disturbing ecotoxicological effort enantiomer enantioselective enantioselectivity enantiospecific expended fate formulated impede metabolite metabolites pollutants pops preferential stereostructural stereostructure stereostructures	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Intersection) ?		pc12