AVEN

Description		apoptosis and caspase activation inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Malaria ( 31844061)
Novel Interacting Genes		1 novel interacting genes: PMPCA
Interacting Genes		4 interacting genes: APAF1 BCL2L1 SMURF1 UBC
Entrez ID		57099
HPRD ID		05588
Ensembl ID		ENSG00000169857
Uniprot IDs		Q9NQS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Mitochondrion Apoptotic Process In Bone Marrow Cell Engulfment Of Target By Autophagosome Mitochondrial Processing Peptidase Complex Apoptosome Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Protein Processing Involved In Protein Targeting To Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To DNA Damage Checkpoint Signaling Cysteine-type Endopeptidase Activator Activity Response To Cycloheximide Bcl-2 Family Protein Complex Negative Regulation Of Dendritic Cell Apoptotic Process BH3 Domain Binding Negative Regulation Of Execution Phase Of Apoptosis Mitochondrial Outer Membrane Proteolysis Mitochondrial Protein Processing Activin Receptor Binding Substrate Localization To Autophagosome Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Striated Muscle Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Tag Activity Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Transforming Growth Factor Beta Receptor Binding Regulation Of Apoptotic Signaling Pathway Muscle Cell Apoptotic Process Hepatocyte Apoptotic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Ectopic Germ Cell Programmed Cell Death Mitochondrial Matrix Negative Regulation Of Anoikis I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Inner Membrane Negative Regulation Of Membrane Permeability Positive Regulation Of Dendrite Extension
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