RPGRIP1 and AEN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RPGRIP1	AEN
Description		RPGR interacting protein 1	apoptosis enhancing nuclease
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Microtubule Cytoskeleton Photoreceptor Connecting Cilium Cell Projection Neuron Projection Intercellular Bridge Non-motile Cilium Photoreceptor Distal Connecting Cilium	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Protein Binding	Nucleic Acid Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Visual Perception Eye Photoreceptor Cell Development Retinal Rod Cell Development Retina Development In Camera-type Eye Neural Precursor Cell Proliferation Non-motile Cilium Assembly	DNA Metabolic Process RNA Processing Apoptotic Process DNA Damage Response Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	36 interacting genes: EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473
Entrez ID		57096	64782
HPRD ID		05673	08573
Ensembl ID		ENSG00000092200	ENSG00000181026
Uniprot IDs		Q96KN7	Q8WTP8
PDB IDs		4QAM
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleus Regulation Of RNA Biosynthetic Process Ciliary Basal Body	Keratin Filament Intermediate Filament Identical Protein Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Zinc Ion Binding Regulation Of RNA Splicing Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Macromolecule Biosynthetic Process
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