RPGRIP1 and TBC1D7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RPGRIP1	TBC1D7
Description		RPGR interacting protein 1	TBC1 domain family member 7
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Microtubule Cytoskeleton Photoreceptor Connecting Cilium Cell Projection Neuron Projection Intercellular Bridge Non-motile Cilium Photoreceptor Distal Connecting Cilium	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle TSC1-TSC2 Complex Ciliary Basal Body
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Small GTPase Binding TSC1-TSC2 Complex Binding
	Biological Process	Visual Perception Eye Photoreceptor Cell Development Retinal Rod Cell Development Retina Development In Camera-type Eye Neural Precursor Cell Proliferation Non-motile Cilium Assembly	Cellular Response To Starvation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly Negative Regulation Of TORC1 Signaling
Pathways			TBC/RABGAPs
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Migraine ( 23793025) Migraine without aura ( 23793025)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ
Entrez ID		57096	51256
HPRD ID		05673	18165
Ensembl ID		ENSG00000092200	ENSG00000145979
Uniprot IDs		Q96KN7	Q9P0N9 U3KPY5
PDB IDs		4QAM	3QWL 4Z6Y 5EJC 5ULO 7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleus Regulation Of RNA Biosynthetic Process Ciliary Basal Body	Cytosol Cellular Response To Starvation Identical Protein Binding Ubiquitin Protein Ligase Binding Response To Starvation Regulation Of Autophagy Cellular Response To Nutrient Levels Regulation Of Synapse Organization Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macroautophagy Negative Regulation Of Protein Localization Protein Domain Specific Binding Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization To Nucleus Sodium Channel Inhibitor Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Maternal Placenta Development Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Regulation Of Protein Localization Cytoskeleton Potassium Channel Inhibitor Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen Levels Response To Nutrient Levels Nuclear Envelope Lumen Anoikis TORC1 Signaling Protein Localization To Membrane Regulation Of Dendrite Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Sodium Ion Transport Vacuole Organization Negative Regulation Of Sodium Ion Transport Phosphatidylethanolamine Binding Positive Regulation Of Catabolic Process Response To Stress Positive Regulation Of Fibroblast Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis TOR Signaling Regulation Of Protein Catabolic Process Cell Projection Organization
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