AEN and RALYL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AEN	RALYL
Description		apoptosis enhancing nuclease	RALY RNA binding protein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding Hydrolase Activity	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	DNA Metabolic Process RNA Processing Apoptotic Process DNA Damage Response Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)	Adult body size ( 32376654) Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systolic blood pressure ( 27841878) Trunk fat mass ( 28552196)
Interacting Genes		36 interacting genes: EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473	25 interacting genes: ADISSP AEBP2 AEN BYSL CAMK2A CCDC85B CEP170P1 EWSR1 EXOSC7 FXR1 FXR2 HNRNPC LMO3 LRRK2 MBD2 MCRS1 NXF1 PCBP2 PSMF1 RBM41 THAP1 TIGD3 TSC1 TSNAX ZNF408
Entrez ID		64782	138046
HPRD ID		08573	11236
Ensembl ID		ENSG00000181026	ENSG00000184672
Uniprot IDs		Q8WTP8	B3KT61 Q86SE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Zinc Ion Binding Regulation Of RNA Splicing Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Macromolecule Biosynthetic Process	Nucleic Acid Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus RNA Binding MRNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleolus Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Translation Regulator Activity Cytoplasmic Stress Granule Nucleoplasm Regulation Of RNA Metabolic Process Protein Homodimerization Activity Poly(U) RNA Binding Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening MRNA 3'-UTR AU-rich Region Binding MRNA Transport Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Hydrolase Activity Peptidyl-threonine Autophosphorylation Neuron Projection Negative Regulation Of Telomere Maintenance Memory T Cell Differentiation Negative Regulation Of Macroautophagy RNA Transport Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleosomal DNA Binding Presynaptic Modulation Of Chemical Synaptic Transmission Nucleolus Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of MRNA Stability U12 SnRNA Binding
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