AEN and MBNL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AEN	MBNL1
Description		apoptosis enhancing nuclease	muscleblind like splicing regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleic Acid Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding Hydrolase Activity	RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA Metabolic Process RNA Processing Apoptotic Process DNA Damage Response Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	In Utero Embryonic Development MRNA Processing Nervous System Development RNA Splicing Embryonic Limb Morphogenesis Regulation Of RNA Splicing Myoblast Differentiation
Pathways
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) End-stage renal disease ( 29885931) Fasting glucose ( 34059833) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Infantile hypertrophic pyloric stenosis ( 22306654) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Prostate cancer ( 29892016) Type 2 diabetes ( 30054458 30297969 32499647) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) White blood cell count ( 32888494)
Interacting Genes		36 interacting genes: EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473	21 interacting genes: ABI3BP AEN APP BCAS2 BIN1 CEBPA DAB1 DMRTB1 FBXO7 IDH3A ITSN2 PKM PRPF39 QKI RBFOX2 RBPMS RPL21 SNRPA TLE5 UBC ZNHIT3
Entrez ID		64782	4154
HPRD ID		08573	07355
Ensembl ID		ENSG00000181026	ENSG00000152601
Uniprot IDs		Q8WTP8	A0A0A0MQX8 C9JP00 Q86VM6 Q9NR56
PDB IDs			3D2N 3D2Q 3D2S 5U6H 5U6L 5U9B
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Zinc Ion Binding Regulation Of RNA Splicing Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Macromolecule Biosynthetic Process	Regulation Of Astrocyte Differentiation RNA Processing Nucleus RNA Splicing Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Gliogenesis MRNA Binding MRNA Processing U1 SnRNP Negative Regulation Of Cell Development Negative Regulation Of Blood Circulation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Positive Regulation Of Glial Cell Differentiation Synaptic Vesicle Endocytosis Lipid Tube Positive Regulation Of Developmental Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Nucleic Acid Binding MRNA Metabolic Process Regulation Of MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Presynaptic Endocytosis Vesicle Dendrite Development Macrophage Differentiation Regulation Of RNA Splicing Regulation Of Neuron Differentiation RNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid Precursor Protein Catabolic Process Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle
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